Loading clinical trials...

Anti-hypertensive Medication Dosing Regimen in Effective Blood Pressure Control | Clinical Trials | Clareo Health

COMPLETEDPHASE4

Anti-hypertensive Medication Dosing Regimen in Effective Blood Pressure Control

Hellenic Anglo Research Into Morning Or Evening Antihypertensive Drug deliverY Trial

NCT01669928•Imperial College London

Summary

A randomised crossover trial of anti-hypertensive medication dosing regimen in effective blood pressure control. To investigate whether there is a difference in 24 hour blood pressure (BP) control when antihypertensive medications are taken in the morning compared with the evening.

Detailed Description

The identification of any significant difference could lead to more effective therapeutic management of arterial hypertension, which in turn would result in a reduced cardiovascular burden, lower costs and a better quality of life for hypertensive patients.

Eligibility

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Caucasian patients aged 18-80 years;
•History of any grade of hypertension for at least 1 year, including at least 3 months of constant antihypertensive medication (consisting of ≥ 1 antihypertensive drugs, each administered in one dose daily), with reasonably controlled BP (≤150/90 mmHg and ≥ 115/75 mmHg on usual medication) based on previous clinic records, in the last 3 months.

Exclusion Criteria

•BP levels \> 150/90 mmHg or \< 115/75 mmHg in the last 3 months.
•Postural hypotension, defined as symptoms resulting from a \> 20 mm Hg drop of systolic BP or a \> 10 mm Hg drop of diastolic BP or both between 1 and 3 min after standing from the sitting position.
•Known Extreme dippers at baseline (fall of mean night time SBP \> 20% of mean day time SBP)
•Individuals with jobs which require night-time shift work.
•Pregnant women or those planning to become pregnant.

Locations (2)

Aristotle University of Thessaloniki

Thessaloniki, Greece

Imperial Clinical Trials Unit

London, United Kingdom

Key Dates

Start Date

April 1, 2012

Primary Completion Date

July 1, 2015

Completion Date

July 1, 2015

Last Updated

March 8, 2021

Enrollment

103

ACTUAL participants

Conditions

Hypertension

Interventions

Anti-hypertensive Medication -

DRUG

Natural History of Noncirrhotic Portal Hypertension

NCT02417740

Cystic FibrosisImmunologic Deficiency Syndrome+3 more

View study

RECRUITINGPHASE2

A Study to Learn About the Study Medicine (Called PF-07868489) in People With Pulmonary Arterial Hypertension Who Have Previously Participated in a Clinical Study With PF-07868489

NCT07073820

Pulmonary Hypertension

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 8, 2021Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Anti-hypertensive Medication Dosing Regimen in Effective Blood Pressure Control

Inclusion Criteria

Exclusion Criteria

Natural History of Noncirrhotic Portal Hypertension

A Study to Learn About the Study Medicine (Called PF-07868489) in People With Pulmonary Arterial Hypertension Who Have Previously Participated in a Clinical Study With PF-07868489

Homocysteine and Early Diastolic Dysfunction in Newly Diagnosed Hypertension

Mobile Cued Adherence Therapy (mCAT) for Blood Pressure Medication

Penn Medicine Healthy Heart

Preliminary Human Trials of F230 Tablets