Conselho Nacional de Desenvolvimento Científico e Tecnológico
Age
18–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Patients aged between 18 and 75
2. With systolic blood pressure\> 160 mmHg and \<220mmHg and / or diastolic\> 100 mmHg in the sitting position and according to Brazilian Guidelines on Hypertension (perform steps by obtaining two consecutive measurements differing by less than 4 mmHg between them, calibrated using a sphygmomanometer)
3. Patient regularly enrolled in participating center
You may not be if
1. Systolic blood pressure\> 220 mmHg
2. Patients with cardiovascular events (stroke, AMI, etc.). or cardiovascular procedures with less than 6 months of evolution
3. Renal stages IV and V (glomerular20 filtration estimated by MDRD formula \<30 ml / min; where MDRD = 186 x (S\_Cr) -1.154 x (age) -0.203 x (0.742 if fem.) x (1.210 if Afro-amer. ))
4. Heart failure class III and IV
5. History of malignant disease with life expectancy \< 2 years
6. Alcoholism
7. Psychiatric illnesses that prevent compliance with the Protocol
8. Women of childbearing age who are not in use of effective contraception
9. Pregnancy
10. Arrhythmias, valvular heart disease, AV block 2 and 3 degrees without MP
11. Hepatic impairment
12. Patients with a history of hypersensitivity to any of the drugs under study
13. Examination of the fundus: Grade III and Grade IV
Clareo Health | Resistant Hypertension Optimal Treatment
