Surgery or Chemotherapy in Recurrent Ovarian Cancer (SOC 1 Trial)?

Exclusion Criteria

• •Patients with borderline tumors as well as non-epithelial tumors.
• •Patients for interval-debulking, or for second-look surgery, or palliative surgery planned.
• •Impossible to assess the resectability or evaluate the score. Radiological signs suggesting complete resection is impossible.
• •More than one prior chemotherapy.
• •Second relapse or more
• •Patients with second or other malignancies who have been treated by surgery, if the treatment might interfere with the treatment of relapsed ovarian cancer or if major impact on prognosis is expected.
• •Progression during chemotherapy or recurrence within 6 months after first-line therapy
• •Any contradiction not allowing surgery and/or chemotherapy
• •1. Accompanied by hypoxia serious chronic obstructive pulmonary disease
• •2. Uncontrolled hypertension, cerebrovascular accident/ Stroke, myocardial infarct, unstable angina, untreated thrombosis, chronic congestive heart failure, or serious arrhythmia in need of medicine.
• •3. Severe hepatitis, history of liver disease, nephrotic syndrome, renal insufficiency
• •4. Active ulcer history, abdominal wall fistula, perforation of gastrointestinal tract, or Intra-abdominal abscess, or simultaneously apply treatment/prevent ulcers therapy.
• •5. Uncontrolled diabetes
• •6. Uncontrolled epilepsy need long-term antiepileptic treatment.
• •Any medication induced considerable risk of surgery, e.g. estimated bleeding due to oral anticoagulating agents, or bevacizumab.