Study of Acute Normovolemic Hemodilution (ANH) in People With Ovarian Cancer Who Are Having Cytoreductive Surgery

Inclusion Criteria

• •Adults (≥18 years)
• •BLOODS score ≥2 as calculated by surgeon
• •High preoperative suspicion (or diagnosis) of advanced primary epithelial ovarian, fallopian tube, or primary peritoneal carcinoma (stage IIIC or IV), as determined by CT or MRI of the abdomen/pelvis
• •Planned for exploratory laparotomy and primary or interval cytoreductive surgery
• •Preoperative hemoglobin concentration ≥10 mg/dl within 45 days of surgery
• •Patients scheduled for cytoreductive surgery, with or without other planned procedures o Note: Patients scheduled for only diagnostic laparoscopy should not be included
• •A history of cerebrovascular disease
• •A history of congestive heart failure
• •A history of uncontrolled hypertension
• •A history of restrictive or obstructive pulmonary disease
• •A history of renal dysfunction (Cr \>1.6 mg/dl)
• •Abnormal coagulation parameters (INR \>1.5 not on coumadin, or platelet count \<100,000 mcL)
• •Presence of active infection
• •Evidence of hepatic metabolic disorder (bilirubin \>2 mg/dl, ALT \>75 U/L in the absence of biliary tract obstruction)
• •Preoperative autologous blood donation within last 30 days or plan to donate autologous blood prior to surgery
• •Refusal to accept allogenic or autologous blood transfusion
• •Patients scheduled for cytoreductive surgery with planned Hyperthermic Intraperitoneal Chemotherapy (HIPEC)