Magnesium Sulfate Versus 5% Dextrose With Treatment Resistant Depression

Exclusion Criteria

• •1. Currently enrolled (or have been in the last 30 days) in another research trial for investigative nutritional or other therapies thought to have an impact on depression.
• •2. Currently taking a medication or nutritional supplement containing more than 100% RDA of magnesium (for women over age 31, it is 320 mg/day and for men over age 31, it is 420 mg/day) and unable to discontinue using it 14 days prior to the Day 1 visit. (Current use must be stopped 2 weeks before enrolling in the study and during trial.)
• •3. Diagnosed with any medical condition, including diabetes, cardiovascular disease, pulmonary, renal, endocrine, hepatic, neurologic, psychiatric (except for depression), immunologic, hematologic, gastrointestinal, or metabolic disease requiring medical treatment that would preclude participation in the study.
• •4. Taking Digoxin (used to treat congestive heart failure and to slow the heart rate in patients with atrial fibrillation.
• •5. Taking penicillamine (also known as Cuprimine or Depen for Wilson's disease or rheumatoid arthritis).
• •6. Taking any antibiotic (including tetracycline or a quinolone).
• •7. Taking any psychotropic medication for any indication, except sedatives for sleep such as Zolpidem, in addition to the SSRI, SNRI, NRI, tricyclic antidepressant, or bupropion in the course of treatment for your depression.
• •8. Taking a SSRI, SNRI, NRI, tricyclic antidepressant, or bupropion for less than 90 days or unable to maintain the same therapeutic regimen throughout the study duration.
• •9. A history of any medical or surgical procedure that would preclude participation in the study.
• •10. Diagnosed with gastrointestinal disorders that could lead to uncertain resorption of the study supplements.
• •11. Pregnant, plan to become pregnant, or currently breast feeding.
• •12. Unwilling to avoid pregnancy (use medically-acceptable birth control method during the study with at least one method for the period of one month prior to beginning of the study until at least three months after study completion or are surgically sterile or postmenopausal (at least 12 months without a period).
• •13. Systolic blood pressure \>160 mmHg or diastolic blood pressure \>90 mmHg.
• •14. Had any of the following abnormal laboratory test values: (a) bilirubin \> 2x upper normal limit, (b) AST and ALT \> 2x upper normal limit, (c) serum creatinine \> 1.5 mg/dl, (d) blood glucose below 80 mg/dl or above 110 mg/dl, (e) calcium level \< 8.6 mg/dl, or (f) triglycerides \>200 mg/dl.
• •15. Currently undergoing any chemotherapy or radiation treatment for cancer, have an active malignancy, or have had within the past 5 years any type of malignancy, other than non-melanomatous skin malignancies.
• •16. A history of substance abuse (e.g., alcohol, opiates, benzodiazepines, or amphetamines).
• •17. Currently consume more than 6 standard alcoholic drinks a week (A standard alcoholic drink is defined as one bottle/can of beer, one glass of wine, or one ounce of hard liquor.).
• •18. Diagnosed with a terminal illness.
• •19. Donated blood in the last 30 days.
• •20. Any severe, acute illness within the last five days.
• •21. Have a pacemaker or internal medical device.