High Dose Vitamin C in the Critically Ill Patient

Exclusion Criteria

• •Age less than 18 years.
• •Pregnant women.
• •Creatinine of greater than 2.2 g/dl at time of enrollment, history of chronic kidney or end stage renal disease, rise in creatinine \> 1 g/dl within 24 hours prior to enrollment.
• •Brain death diagnosed within 4 hours of presentation to the trauma bay or intensive care unit
• •Patients with history of hemolytic blood disease, e.g. glucose-6-phosphate dehydrogenase deficiency, Sickle Cell Disease and Thalassemia.
• •Patients in isolated cardiogenic shock.
• •History of liver cirrhosis
• •Transplant patients (liver, kidney, heart)