TOP-Study (Tacrolimus Organ Perfusion): Treatment of Ischemia Reperfusion Injury in Marginal Organs With an ex Vivo Tacrolimus Perfusion

Inclusion Criteria

• •Recipient:
• •Chronical terminal liver failure, age \> 18 years, first organ transplantation
• •Donor:
• •donor age \> 65 Jahre
• •macrovesicular steatosis \> 40% (macroscopy or biopsy)
• •BMI \> 30
• •sodium \>165 mmol/l
• •ICU stay and ventilation \> 7 days
• •cold ischemia time \> 13 hours
• •AST \> 99 U/l
• •ALT \> 105 U/l
• •bilirubin \> 3 mg/dl (\> 51 µmol/l)
• •application of epinephrine