NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial

Inclusion Criteria

• •Informed consent before any study-related activities.
• •Men or women \>18 years of age who are scheduled for non-emergent cardiac surgery procedures requiring CPB and are at increased risk for surgery-related adverse cardiovascular outcomes.
• •Procedures include:
• •CABG
• •Aortic, mitral, tricuspid, or pulmonic valve replacement or repair
• •CABG with aortic, mitral, tricuspid, and/or pulmonic valve replacement
• •Risk factors for surgery related to adverse cardiovascular outcomes include one or more of the following:
• •Valve surgery
• •eGFR \< 45 ml/min/1.73m2
• •Documented LVEF ≤ 35% within six months before surgery
• •Documented history of heart failure
• •Insulin-requiring diabetes
• •Non-insulin-requiring diabetes and the presence of ≥+2 proteinuria on urinalysis (or equivalent on urine protein-to-creatinine ratio or urine albumin-to-creatinine ratio)
• •Preoperative anemia (hemoglobin \<11g/dl for men and women)
• •History of prior CABG
• •Age ≥65