Study on Delayed Graft Function Using Paired Kidneys

Exclusion Criteria

• •1. Mean arterial pressure \<40 mmHg or cardiac index \<1.8 L/min/m2.
• •2. Recipient of multiple organ transplantation or scheduled for multiple organ transplantation.
• •3. Recipient of kidney from a pediatric donor age 10 years or less.
• •4. Recipient age \> 75 years.
• •5. Patients with ASA 4 or 5
• •6. Patients with chronic obstructive pulmonary disease (COPD) GOLD IV
• •7. Has measurable donor-specific antibody or positive cross-match requiring deviation from standard immunosuppressive therapy.
• •8. Currently participating in or has participated in an investigational drug or medical device study within 30 days or five half-lives, whichever is longer, prior to enrolment into this study.
• •9. Concurrent sepsis or active bacterial infection.
• •10. Have an active malignancy or history of solid, metastatic or hematologic malignancy with the exception of basal or squamous cell carcinoma of the skin that has been removed.
• •11. Women of child bearing potential who is breast feeding.
• •12. History of positive HIV test.
• •13. History of rheumatoid arthritis.
• •14. History of proliferative retinopathy or laser surgery for retinopathy.
• •15. Subjects who have a penicillin allergy.
• •16. Subjects who require the cytochrome P450 1A2 (CYP1A2) inhibitors, or are receiving ciprofloxacin and fluvoxamine (Luvox®).
• •17. Subject is unwilling or unable to comply with the protocol or to cooperate fully with the Investigator or the site personnel.
• •18. Subject is not deemed medically stable for the study in the opinion of the Investigator or the subject's primary nephrologist.