Trial of Resistance and Endurance Exercise in Amyotrophic Lateral Sclerosis (ALS)

Exclusion Criteria

• •1. Participants who are already performing \>30 min. of endurance exercise/day for ≥ 3x/week (Borg scale-- "hard" or "somewhat hard") within 30 days of screening.
• •2. Participants who are already performing resistance exercise ≥ 3x/week within 30 days of screening.
• •3. Neurologic
• •* Participants with history of ALS symptoms over 5 years duration
• •* Inability to obtain consent (psychiatric or dementing illness)
• •* History of neuromuscular dysfunction not related to ALS
• •4. Cardiac
• •* Patents with clinically significant ECG abnormalities
• •* Uncontrolled hypertension (SBP\>160 or DBP\>110)
• •* Recent history of angina (within the last 2 years)
• •* Recent history of abnormal stress test (within the last 2 years)
• •* Symptomatic severe aortic stenosis
• •* Active endocarditis
• •* Symptomatic heart failure
• •5. Respiratory
• •* Subjects with a history of respiratory dysfunction not related to ALS (i.e. COPD)
• •6. General
• •* Subjects with chronic infectious disease including HIV, hepatitis B or C.
• •* History of substance abuse within the past year
• •* Patients who have a history of poor compliance to medical regimens or study requirements.
• •* Uncontrolled diabetes
• •* Recent embolism (within the last 6 months)
• •* Severe orthopedic conditions that would prohibit exercise
• •7. Pregnancy
• •* Female subjects who are pregnant or planning to become pregnant.
• •* Female subjects of childbearing potential who are not practicing contraception.