Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Johns Hopkins University
With
ALS Association
Age
18–80
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Participants with familial or sporadic ALS diagnosed as possible, laboratory-supported probable, probable, or definite according to the WFN El Escorial criteria
2. Participants who are ages 18-80, inclusive.
3. Slow Vital Capacity (SVC) must be equal to or greater than 70% of predicted value
4. ALSFRS-R score \>30.
5. Patients who are currently on any medications must be on a stable dose for the past 30 days.
6. Participants must provide informed consent prior to completion of any study procedures.
You may not be if
1. Participants who are already performing \>30 min. of endurance exercise/day for ≥ 3x/week (Borg scale-- "hard" or "somewhat hard") within 30 days of screening.
2. Participants who are already performing resistance exercise ≥ 3x/week within 30 days of screening.
3. Neurologic
* Participants with history of ALS symptoms over 5 years duration
* Inability to obtain consent (psychiatric or dementing illness)
* History of neuromuscular dysfunction not related to ALS
4. Cardiac
* Patents with clinically significant ECG abnormalities
* Uncontrolled hypertension (SBP\>160 or DBP\>110)
* Recent history of angina (within the last 2 years)
* Recent history of abnormal stress test (within the last 2 years)
* Symptomatic severe aortic stenosis
* Active endocarditis
* Symptomatic heart failure
5. Respiratory
* Subjects with a history of respiratory dysfunction not related to ALS (i.e. COPD)
6. General
* Subjects with chronic infectious disease including HIV, hepatitis B or C.
* History of substance abuse within the past year
* Patients who have a history of poor compliance to medical regimens or study requirements.
* Uncontrolled diabetes
* Recent embolism (within the last 6 months)
* Severe orthopedic conditions that would prohibit exercise
7. Pregnancy
* Female subjects who are pregnant or planning to become pregnant.
* Female subjects of childbearing potential who are not practicing contraception.
Clareo Health | Trial of Resistance and Endurance Exercise in Amyotrophic Lateral Sclerosis (ALS)
