Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Zhejiang Cancer Hospital
Brain metastases occur in 25-40% of patients with non-small cell lung cancer (NSCLC). It is one of the primary reasons resulting in treatment failure and the death. Whole-brain radiation therapy (WBRT) is the standard approach to the treatment of multiple brain metastases from NSCLC. Regardless of the treatment of brain metastases by WBRT combined with systemic chemotherapy,outcomes of NSCLC with brain metastases are still very poor. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) can pass through the blood-brain barrier and show promising antitumor activity against brain metastases from NSCLC. Icotinib shows nearly the same effect as gefitinib in advanced NSCLC patients failed with chemotherapy.
Age
18–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Cytologic or histological diagnosis of non-small cell lung cancer
Patients with disease progression after systemic chemotherapy with two-drug combination regimens that includes a platinum agent or patients with EGFR mutation status who have not been treated
Patients are diagnosed with multiple brain metastases for the first time in 4 weeks
Diagnosis of brain metastases is made based on Magnetic resonance imaging (MRI).
Doctors consider the patient will benefit from WBRT
No prior brain radiotherapy
ECOG performance status 0-2
age:18-75 years
Neutrophil count ≥1.5×10 to the 9th power/L and platelets≥100×10 to the 9th power/L. hemoglobin ≥90 g/L
Hepatic: total bilirubin less than or equal to 1.5 times upper limit of normal (ULN) Alanine transaminase (ALT) and aspartate transaminase (AST) less than or equal to 2.5 times ULN (or less than or equal to 5 times ULN in case of known liver involvement)
Renal: Serum Creatinine less than or equal to 1.5 times upper limit of normal (ULN)
Patients with measurable brain metastases according to the Response Evaluation Criteria in Solid Tumors (RECIST) criteria
Patients must sign an informed consent indicating that they are aware of the investigational nature of the study
You may not be if
Prior brain radiation therapy
Solitary brain metastasis according to Magnetic resonance imaging (MRI)
Mort than 3 extracranial organs have metastatic lesions
Prior invasive malignancy (skin basal cell cancer, carcinoma in situ of cervix are permissible).
