Whole Brain Radiotherapy Following Local Treatment of Intracranial Metastases of Melanoma

Inclusion Criteria

• •1-3 intracranial metastases on MRI from melanoma, locally treated with either surgical excision and/or stereotactic irradiation.
• •Life expectancy of at least 6 months
• •Aged 18 years or older
• •WBRT must begin within 8 weeks of completion of localised treatment and within 4 weeks of randomisation
• •Able to have an MRI brain scan with contrast. Estimated Glomerular Filtrate Rate (eGFR) is adequate at the discretion of the radiologist and capable of having gadolinium-containing contrast medium for MRI as per practice guidelines
• •Complete localised treatment of all these metastases no more than 6 weeks prior to randomisation
• •An Eastern Cooperative Oncology Group (ECOG) performance status of 2 or less at randomisation
• •CT scan of chest, abdomen and pelvis as a minimum prior to randomisation. Scans must be within 12 weeks of randomisation
• •Serum Lactate Dehydrogenase (LDH) must be = or \< 2 x upper limit of normal
• •Able to provide written informed consent