Intravenous Tapentadol in Post-Bunionectomy Pain

Exclusion Criteria

• •History of malignancy within the past 2 years
• •Current or history of alcohol or drug abuse.
• •Clinically relevant pulmonary, gastrointestinal, endocrine, metabolic, neurological, psychiatric disorders (resulting in disorientation, memory impairment or inability to report accurately
• •History of seizure disorder, epilepsy, or any condition that would put the subject at risk of seizures
• •Severely impaired renal function
• •Moderately or severely impaired hepatic function
• •Contraindications, or a history of allergy or hypersensitivity, to tapentadol, ibuprofen, or excipients
• •Use of prohibited concomitant medication, or not allowed use of restricted concomitant medication