A Clinical Trial for CTD-ILD Treatment

Inclusion Criteria

• •Inclusion:
• •1. Subject gives voluntary written informed consent to participate in the study.
• •2. Subject has been diagnosed with a connective tissue disease and associated interstitial lung disease confirmed by computed tomography of the lungs along with symptoms of cough and/or shortness of breath.
• •3. Males and females age greater than 18 years at time of screening.
• •4. Females of childbearing potential must be willing to use a reliable form of medically acceptable contraception and have a negative pregnancy test confirmed at baseline before starting NAC as per standard of care. Women who are surgically sterile or have been post-menopausal for at least two years are not considered to be of child-bearing potential.
• •Exclusion:
• •1. History of severe chronic kidney disease defined as a glomerular filtration rate of less than 30.
• •2. Hemoglobin concentration less than 70% of the lower limit of the normal range at time of screening.
• •3. Moderate to severe hepatic impairment, i.e., Child-Pugh Class B or C.