Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) Assessment of LIK066 in Healthy Subjects and in Patients With Type 2 Diabetes Mellitus (T2DM)

Exclusion Criteria

• •Patients with type 1 diabetes mellitus.
• •Patients with history of acute diabetic complications within the 6 months prior to screening.
• •Women of child-bearing potential.
• •Patients with signs or symptoms of significant diabetic complications.
• •Patients treated with certain blood pressure or lipid lowering medications unless patients have been on stable doses for the 12 weeks prior to dosing.
• •History of drug or alcohol abuse within the 12 months prior to dosing.
• •Any surgical or medical condition, acute or unstable chronic disease which may, based on the investigator's opinion, jeopardize the patient in case of participation in the study.