Multiple Ascending Dose Trial of BYK324677 in Healthy Volunteers

Exclusion Criteria

• •History or current evidence of specified diseases
• •History of malignancy in the past 5 years
• •Gain or loss in body weight of more than 5% within the last 2 months or use of weight-loss medication within the last 3 months
• •ECG abnormalities of clinical relevance
• •Suspected hypersensitivity to the trial medication
• •Positive virology tests indicating acute or chronic infections
• •Clinically relevant laboratory parameters outside a specified range
• •Use of specified medications within certain time frames or use of certain co-medications
• •Abuse of alcohol or drugs
• •Dietary habits that would prevent from taking standardised meals
• •Female subjects: positive pregnancy test; lack of medically reliable methods of contraception during the trial
• •Donation of blood
• •Smoking within the last 3 months