Diagnosis of Cardio-Pulmonary Pathology Using Transthoracic Parametric Doppler (TPD)

Inclusion Criteria

• •Age 18 years or older Patients who are clinically suspected of having pulmonary, cardiac or Cardio-pulmonary disease preferably any one or more of the conditions listed below:
• •Patients with CHF
• •Patients with pulmonary hypertension with documented right heart catheterization data
• •Patients with COPD in two subgroups:
• •* Emphysema, (evidence of emphysema on High Resolution Computed Tomography, (HRCT) and airflow limitation of GOLD II severity who have had Carbon Monoxide Diffusing capacity, (DLCO) and Residual Volume(RV) measured, or patients without HRCT with measurements of lung volumes and diffusing capacity with Total Lung Capacity (TLC) ≥1.0 predicted, RV/TLC ≥0.4, DLCO ≤ 0.7 predicted.
• •* Chronic Bronchitis (No evidence of Emphysema on HRCT and/or no evidence of air-trapping or reduced DLCO.)
• •Patients with asthma according to ATS/ERS definition,
• •Patients with interstitial lung disease (ILD) of any etiology including sarcoidosis diagnosed by HRCT in sub groups as follows:
• •* Mild ILD (TLC 0.71-0.79 predicted, DLCO ≥ 0.71 predicted)
• •* Moderate and severe ILD (TLC ≤ 0.7 predicted, DLCO ≤ 0.7 predicted)
• •Signed informed consent.
• •Patients with sarcoidosis without evidence of parenchymal lung disease defined as normal DLCO and/or HRCT.