Refractory hypertension (as defined by the WHO: poorly controlled hypertension (\>140/90 mmHg) despite adequate doses of at least three antihypertensive drugs including a diuretic)
Men or women aged \>18 years
Intact peroneal nerve
Written informed consent
You may not be if
Diseases, dysfunctions, or medications (such as NET inhibitors) that exclude a participation in the study according to the investigator.
Legal incompetence or circumstances that interfere with the patient´s ability to fully understand scope, relevance, and/or consequences of participation in this study.
People in custody
hypersensitivity to clonidine, phenylephrine, or nitroprusside-sodium
sick sinus syndrome, second or third degree AV block, bradycardia \< 50 bpm (contraindication for clonidine)
endogenous depression (contraindication for clonidine)
Clareo Health | Sympathetic Activity and Renal Denervation
