Correlation Between Coronary and Carotid Atherosclerotic Disease (CAD) and Links With Clinical Outcomes

Exclusion Criteria

• •Women of childbearing potential (women who are not surgically sterile or postmenopausal defined as amenorrhea for \>12 months) who refuse to undergo a urine or serum pregnancy test immediately prior to baseline and repeat imaging evaluations The urine or serum pregnancy test must be negative prior to imaging evaluations.
• •Previous coronary artery bypass graft (CABG) surgery or probable need for CABG in the next 24 months.
• •Patients who have symptomatic congestive heart failure (CHF) (New York Heart Association \[NYHA\] Class III or IV) at baseline.
• •Patients with clinically significant valvular heart disease likely to require surgical repair or replacement during the treatment period of the study
• •Any clinically significant medical condition or presence of any laboratory abnormality that is considered by the investigator to be clinically important and could interfere with the conduct of the study.
• •The presence of severe liver disease as defined by the presence of cirrhosis, chronic active hepatitis, or chronic jaundice with hyperbilirubinemia,
• •Patients with eGFR \< 45 ml/min prior to baseline imaging procedures, or with nephrotic syndrome
• •Patients with a life expectancy less than 2 years.
• •History of malignancy (except for curatively treated basal cell or squamous cell carcinoma of the skin) during the 3 years prior to the screening.
• •Unable or unwilling to comply with protocol requirements, or deemed by the investigator to be unfit for the study.