Loading clinical trials...
Loading clinical trials...
Optimal Surgery With Total Mesorectal Excision and MRI Based Multimodal Therapy of Rectal Carcinoma
The objective of the study is to provide proof that a MRI based preoperative radiochemotherapy in patients with locally advanced rectal carcinoma allows limiting RCT to high risk patients without increase of locoregional recurrence rate and decrease of overall survival provided there is a high quality of mesorectal excision.
The criteria for application of RCT is the distance of the tumor from mesorectal fascia in preoperative MRI of the pelvis. In case of a T 4 tumor or a tumor with a distance of 1mm of less form mesorectal fascia long-course radiochemotherapy is applied followed by surgery, in all other cases primary surgery is done.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
University Medicine Center Department of General and Abdomial Surgery
Mainz, Germany
Start Date
February 1, 2009
Primary Completion Date
September 1, 2016
Completion Date
September 1, 2016
Last Updated
October 19, 2016
1,051
ACTUAL participants
total mesorectal excision / long course radiochemotherapy
PROCEDURE
long course 5-FU bases radiochemotherapy
RADIATION
Lead Sponsor
Johannes Gutenberg University Mainz
NCT07328087
NCT07018869
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and Conditions