BIBW 2992 (Afatinib) for the Treatment of Patients With HER2-positive, Hormone-refractory Prostate Cancer

Exclusion Criteria

• •Prior treatment with EGFR/HER2-targeted small molecules or antibodies, i.e. trastuzumab and/or lapatinib
• •Known pre-existing interstitial lung disease
• •Radiotherapy, chemotherapy, hormone therapy (with the exception of GnRH agonists), immunotherapy or surgery (other than biopsy) within 4 weeks prior to start of treatment with BIBW2992. GnRH-agonists are allowed at the discretion of the investigator.
• •Active brain metastases (defined as stable for \< 4 weeks and/or symptomatic and/or requiring changes of treatment with anticonvulsants or steroids within the past 4 weeks and/or leptomeningeal disease). Patients with known history of brain metastases should undergo a baseline brain image to ensure that the disease is stable.
• •Any other current malignancy or malignancy diagnosed within the past five (5) years (other than non-melanomatous skin cancer).
• •Significant or recent acute gastrointestinal disorders with diarrhoea as a major symptom, e.g. Crohn's disease, malabsorption or CTC grade ≥ 2 diarrhoea of any aetiology.
• •History or presence of clinically relevant cardiovascular abnormalities such as uncontrolled hypertension, congestive heart failure NYHA classification of 3, unstable angina or poorly controlled arrhythmia. Myocardial infarction within 6 months prior to randomisation.
• •Cardiac left ventricular function with resting ejection fraction of less than 50%.
• •Any other concomitant serious illness or organ system dysfunction which in the opinion of the investigator would either compromise patient's safety or interfere with the evaluation of the safety of the test drug.
• •Absolute neutrophil count (ANC) \< 1500 / mm³.
• •Platelet count \< 75,000 / mm³
• •Calculated creatinine clearance \< 60 ml / min (using Cockcroft-Gault formula for GFR estimate) or serum creatinine \> 1.5 times upper limit of normal.
• •Uncontrolled hypercalcemia
• •Patients unable to comply with the protocol.
• •Known hepatitis B infection, known hepatitis C infection or known HIV carrier.
• •Known or suspected active drug or alcohol abuse.
• •Requirement for treatment with any of the prohibited concomitant medications
• •Any contraindications for therapy with BIBW 2992.
• •Known hypersensitivity to BIBW 2992.
• •Use of any investigational drug within 4 weeks of start of treatment