Study of BGG492 in Patients With Chronic Subjective Tinnitus

Exclusion Criteria

• •Patients diagnosed with tinnitus of THI severity grade equal to 2 or 1
• •Patients with diagnosis of intermittent or pulsatile tinnitus
• •Patients who have tinnitus as a concomitant symptom of a treatable otological disease (such as otitis media, Menière's disease, otosclerosis), neurological tumors or/and have temporo-mandibular joint disorders
• •Patients with a history of frequent middle ear infections (\> 3 infections per year during the last 3 years)
• •Patients with diagnosed anxiety disorders, depression, schizophrenia or other significant psychiatric diseases requiring current drug treatment or patients who required treatment in the previous 3 months for these diseases.
• •Patients with current unilateral or bilateral hearing loss of 75 dB or more in one or more tested frequencies (125 Hz, 250 Hz, 1 kHz, 2 kHz, 4 kHz, 6 kHz, 8 kHz)
• •Patients with Vestibular Schwannoma
• •Patients with a cochlear implant
• •Patients with regular intake of central nervous system acting drugs for the treatment of tinnitus in the previous 6 months prior to initial dosing