Lead Sponsor

Novo Nordisk A/S

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Informed consent obtained
•Body Mass Index (BMI) of 30.0 kg/m\^2 or above
•Body Mass Index (BMI) of 27 kg/m\^2 or above in the presence of co-morbidities of treated or untreated dyslipidemia and/or hypertension
•Stable body weight
•Preceding failed dietary effort

•Known type 1 or type 2 diabetes
•Glycosylated haemoglobin (HbA1c) of 6.5 % or above (Screening visit 1) or FPG of 126 mg/dL (7 mmol/L) or above (Screening visit 2) or 2 hour post-challenge (OGTT) plasma glucose of 200 mg/dL (11.1 mmol/L) or above (Screening visit 2)
•Screening calcitonin of 50 ng/L or above
•Family or personal history of multiple endocrine neoplasia type 2 (MEN2) or familial medullary thyroid carcinoma (FMTC)
•Personal history of non-familial medullary thyroid carcinoma
•History of acute or chronic pancreatitis
•Obesity induced by drug treatment
•Use of approved weight lowering pharmacotherapy
•Previous surgical treatment of obesity
•History of major depressive disorder or suicide attempt
•Uncontrolled hypertension (systolic blood pressure of 160 mmHg or above and/or diastolic blood pressure of 100 mmHg or above)