Lead Sponsor

AstraZeneca

Age

18 - 55 years

Sex

ALL

Healthy Volunteers

Yes

•Part A - Healthy Subjects:
•Healthy male or female of non-reproductive potential subjects between 18 to 45 years-of-age
•Body mass index (BMI) between 18 and 32 kg/m2
•Normal or clinically acceptable physical examination, clinical laboratory values, and ECG
•Part B - Crohn's Subjects:
•Male or female subjects with CD between 18 to 55 years-of-age
•Body mass index (BMI) between 18 and 32 kg/m2
•Normal or clinically acceptable physical examination (PE), clinical laboratory values, and ECG; clinically acceptable PE includes evidence of mild to severe CD
•Diagnosis of ileal or ileo-colonic CD for a minimum of 6 months
•Mild to severe CD defined by a Crohn's Disease Activity Index (CDAI) score equal to or greater than 180 and equal to or less than 450
•Elevated fecal calprotectin and CRP

•Parts A - Healthy Subjects:
•History or evidence of a clinically significant disorder (including psychiatric), condition or disease that would pose a risk to subject safety or interfere with the study evaluation, procedures or completion;
•Recent or on-going infection(s)
•Underlying condition(s) that predisposes the subject to infections
•History of malignancy of any type
•Part B only - Crohn's Subjects:
•History or evidence of a clinically significant disorder (including psychiatric), condition or disease that would pose a risk to subject safety or interfere with the study evaluation, procedures or completion;
•Recent or on-going infection(s)
•Underlying condition(s) that predisposes the subject to infections
•History of malignancy of any type