Long-term Safety and Efficacy Study of LB80380 in the Treatment-naive Patients of Chronic Hepatitis B

Exclusion Criteria

• •Co-infection with hepatitis C or D virus (HCV or HDV) or HIV
• •Decompensated liver disease
• •ALT \> 10 x ULN
• •Creatinine clearance (calculated by cockcroft-gault formula) less than 50 ml/min
• •Alpha-fetoprotein (AFP) value greater than or equal to 50 ng/mL, and a follow-up ultrasonography performed prior to baseline shows findings indicative of HCC
• •Treatment with immunomodulatory agent or corticosteroids within 6 months prior to study entry.
• •Pregnancy or breast-feeding
• •Patient is currently abusing alcohol or illicit drugs
• •Significant systemic illnesses other than liver diseases
• •Presence of other causes of liver disease
• •Plan for liver transplantation