Clareo Health | Effect of Intensive Blood Pressure Control on Progression of Coronary Atherosclerosis: Randomized Evaluation by Intravascular Ultrasound
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Lead
Takeshi Morimoto
Antihypertensive therapy is reported to reduce cardiovascular events in patients with coronary artery disease. The goal of blood pressure in patients with coronary artery disease is recommended to control below 140/90mmHg. However, the effect of intensive blood pressure control compared to standard blood pressure control is still unknown. The purpose of this study is to evaluate the effect of intensive blood pressure control compared to standard blood pressure control on progression of coronary atherosclerosis by intravascular ultrasound in hypertensive patients with coronary atherosclerosis after 18 months. The goal of systolic blood pressure is under 120mmHg in intensive blood pressure control group and under 140mmHg in standard blood pressure control group. The design of this study is randomized control study.
Age
20–79
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
coronary artery diseases which require coronary angiography or percutaneous coronary intervention
primary hypertension (systolic blood pressure 140-180mmHg within one month)
You may not be if
severe hypertension
secondary hypertension
treated with more than three antihypertensive drugs
left main trunk trunk coronary artery disease
moderate heart failure
severe valvular disease
liver dysfunction renal dysfunction (Cr\>=2.0mg/dl) Pregnant or nursing women severe arrhythmia
