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TERMINATEDNANCT01196845

Inflammation and Oxidative Stress of Adipose Tissue in Sleep Apnea Syndrome

The main objective of this study is to evaluate the decrease of inflammation of adipose tissue in obese and non-obese patients having a sleep apnea syndrome and treated or not by continuous positive a...

Lead sponsor: University Hospital, Grenoble•1 locations•View source on ClinicalTrials.gov

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Sponsors

Lead Sponsor

University Hospital, Grenoble

Collaborators

Centre Hospitalier Universitaire de Saint Etienne
Hospices Civils de Lyon
University Hospital, Geneva

Inflammation of adipose tissue will be evaluated by RT-PCR on mRNA of pro and anti-inflammatory cytokines (IL-1, IL-6, IL-4, IL-10, IL-12, RANTES, TNFa, leptin, adiponectin, CD68).

Age

18 - 69 years

Sex

MALE

Healthy Volunteers

No

Inclusion Criteria

•Male between 18 and 70 years old
•Apnea Hypopnea Index \> 30/h and \> 5% TST with SaO2 \< 90%
•patients obese (BMI \> 33kg/m2) or non obese (BMI \< 27kg/m2)

Exclusion Criteria

•Female
•coronary ischemic disease, past history of CVA
•chronic pulmonary disease measured by arterial gasometry (PaO2 \< 60mmHg and/or PaCO2 \> 45mmHg)
•known hepatic disease
•alcohol consumption \> 3 units/day
•sleepiness considered to be dangerous by the investigator
•patient having an hazardous work regarding to awareness
•patient being under anticoagulant, antiplatelet drug or having an active stent or bleeding disorder
•patient having an inflammatory syndrome (C-reactive Protein \> 10)
•any allergy to local anaesthetics
•chronic muscle pain
•contraindication to MRI

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: December 29, 2025Terms

Trial snapshot

StatusTERMINATED

PhaseNA

Enrollment40

Start dateOct 2010

Last updatedDec 29, 2025

Condition

Decrease of Inflammation of Adipose Tissue Sleep Apnea Syndrome

Locations shown

University Hospital Grenoble

Grenoble

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 29, 2025Data synced to Clareo: May 25, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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