Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Mayo Clinic
Age
18–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Cirrhosis documented by biopsy, or suggested by characteristic features on abdominal imaging (nodular appearance, irregular contour) along with impaired synthetic liver function and thrombocytopenia and Child Turcotte Pugh Class A or B.
2. presence of small esophageal varices, defined as varices \< 5 mm in diameter, without red signs documented on endoscopy within 3 months of enrollment
3. age ≥ 18 years
You may not be if
pregnant, lactating or of child-bearing potential and not practicing acceptable method of birth control
allergic to sandostatin
high risk varices on endoscopy carried out within 3 months of assessment (large varices or red signs)
Child Turcotte Pugh Class C cirrhosis
hepatocellular carcinoma
evidence of ongoing alcohol or illicit drug abuse within 6 months of the study
serum creatinine greater than 2 mg/dL
platelet count below 50,000 per microliter
prothrombin time 4 seconds or more greater than control
human immunodeficiency virus (HIV) positive
symptomatic gallstones
previous history of upper gastrointestinal bleeding in the past 3 months, defined as hematemesis and/or melena
previous history of variceal bleeding
history of congestive heart failure , unstable angina, sustained ventricular tachycardia, or ventricular fibrillation
use of any investigational drug within 1 month prior to screening and
current use of beta blockers or long-acting nitrates, any other drug therapy known to have an influence on portal pressure (diuretics were allowed provided patients were on a stable dose for at least 30 days).
