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Lead
Syntara
Two doses of TPI ASM8 will be compared to placebo and look at the effect on asthmatic responses after an allergen challenge during a 3-way cross over design. Sputum inflammation , mRNA gene expression on target receptors, ECP , biomarkers of mast cells activation et PK profile will be studied.
Age
18–55
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Mild asthma, male and female aged 18-55 y.old
Steroid-naive, non-smoker
Dual responders
You may not be if
Any chronic disease(unstable)
Immunosuppressed, recent or ongoing steroid intake
Methacholine PC 20 \> 16 mg/mL
Clareo Health | Efficacy of TPI ASM8 During a 14-Day Allergen Challenge
