Trial of Three Stem Cell Mobilization Regimens for Multiple Myeloma

Exclusion Criteria

• •Patients with (no measurable monoclonal protein, free light chains, and/or M-spike in blood or urine) unless measurable disease is available with imaging techniques such as MRI and PET scan.
• •History of allergic reactions to compounds containing boron, mannitol, VELCADE
• •Prior history of other malignancies (except for basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix or breast) unless disease free for \> = 5 years.
• •NYHA Class III or IV heart disease. History of active unstable angina, congestive heart disease, severe uncontrolled cardiac arrhythmia, electrocardiographic evidence of acute ischemia, active conduction system abnormalities or myocardial infarction within 6 months prior to enrollment. Prior to study entry, any ECG abnormality at Screening has to be documented by the investigator as not medically relevant.
• •Female patients who are pregnant or breastfeeding. Women of childbearing potential and men must agree to use adequate contraception prior to study entry and for the duration of study participation.
• •Known HIV or hepatitis A, B, or C positivity---ONLY IF ACTIVE
• •Active viral or bacterial infections or any coexisting medical problem that would significantly increase the risks of this treatment program.
• •Any concurrent, uncontrolled medical condition, laboratory abnormality, or psychiatric illness which could place him/her at unacceptable risk
• •Patient has \> = Grade 2 peripheral neuropathy within 14 days before enrollment.
• •Patient has received other investigational drugs with 14 days before enrollment
• •Diagnosed or treated for another malignancy within 3 years of enrollment, with the exception of complete resection of basal cell carcinoma or squamous cell carcinoma of the skin, an in situ malignancy, or low-risk prostate cancer after curative therapy.