Study of the Safety and Biologic Activity of XOMA 052 in Subjects With Type 2 Diabetes Mellitus

Exclusion Criteria

• •Significant signs and symptoms of uncontrolled hyperglycemia (i.e., polyuria, polydipsia, or polyphagia)
• •Uncontrolled hypertension (systolic \> 170 mmHg and/or diastolic \> 110 mmHg)
• •Known to be positive for Hep B surface antigen (HBsAg), Hep C virus (HCV), or HIV
• •History of allergic or anaphylactic reactions to humanized or murine monoclonal antibodies
• •Advanced stage heart failure (New York Heart Association \[NYHA\] class 3 or 4)
• •Pulmonary disease requiring medication other than inhaled corticosteroid s
• •History of tuberculosis or positive PPD test.
• •Active leg, foot, or decubitus ulcer
• •Any significant inflammatory, rheumatologic, or systemic autoimmune disease
• •History or any symptoms of a demyelinating disease
• •History of severe non-proliferative or proliferative retinopathy