Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Hanmi Pharmaceutical Company Limited
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
18 aged or over
Patients with blood pressure measured at Visit 1; MSSBP≤180mmHg and MSDBP≤110 mmHg if on anti-hypertensive drugs, 160mmHg≤MSSBP≤199mmHg and 80mmHg≤MSDBP≤119mmHg if not on anti-hypertensive drugs
Patients with blood pressure measured at Visit 2 were 160mmHg≤MSSBP≤199mmHg and 80mmHg≤MSDBP≤119mmHg
You may not be if
Inability to stop all prior anti-hypertensive drugs safely during wash out period of 3 to 7 days
≥ sitSBP 20mmHg or ≥ sitDBP 10mmHg of variation in three measurements from the reference arm selected at Screening
History of hypersensitivity to dihydropyridines, angiotensin II receptor blockers or thiazide diuretics
Secondary hypertension or suspected to be
Continuously took medicinal drugs that might affect blood pressure rather than anti-hypertensive drugs more than 3 months
Type 2 diabetes mellitus which is not controlled or with type 1 diabetes mellitus
History of severe neurovascular disease, severe heart disease
Known as moderate or malignant retinopathy.
Renal diseases; serum creatinine ≥ 2mg/dl
Hepatic diseases; increase in ALT or AST ≥ 2xUNL
Anuria
Hyponatremia/hypokalemia or hypercalcemia
Active Gout
Surgical or medical diseases which might significantly change ADME of medicines
History of malignant tumor
Autoimmune diseases
History of alcohol or drug abuse
Positive to pregnancy test, nursing mother, woman with an intention of pregnancy
Considered inappropriate to participate in the clinical trial with any reason, based on investigator's decision
Clareo Health | Efficacy/Safety of Amlodipine Plus Losartan Versus Amlodipine in Patients With Stage 2 Hypertension
