Lead Sponsor

Samsung Medical Center

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•histologically confirmed small-cell lung cancer
•limited disease status
•with evaluable disease
•18 years or older
•ECOG performance status 0,1,2
•expected survival time should be 12 weeks or longer
•Adequate organ function as evidenced by the following; Absolute neutrophil count \> 1.5 x 109/L; platelets \> 100 x 109/L; total bilirubin ≤1.5 UNL; AST and/or ALT \< 5 UNL; creatinine clearance ≥ 50mL/min
•Written informed consent form

•1. Uncontrolled systemic illness such as DM, CHF, unstable angina, hypertension or arrhythmia
•2. Patients with active infection requiring antibiotics
•3. Pregnant or nursing women ( Women of reproductive potential have to agree to use an effective contraceptive method)
•4. Prior history of malignancy within 5 years from study entry except for a adequately treated basal cell or squamous cell skin cancer or in situ cervical cancer, well-treated thyroid cancer
•5. previous history of chemotherapy or radiotherapy