Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Emory University
With
National Center for Complementary and Integrative Health (NCCIH)
The main outcome of interest is the mean nighttime blood pressure. The investigator is also trying to see the mechanism of action of melatonin on blood pressure by analyzing data from sleep studies to see if melatonin lowers blood pressure by providing a better quality of sleep or is that independent of the quality of sleep.
The investigator is also looking into the effect of melatonin on sympathetic nervous system by measuring urinary catecholamines.
Finally, the investigator is looking into changes in vascular biology markers P-selectin and e-selectin) on Melatonin.
Age
18–64
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Males or females ages 18 to 64
Prior history of elevated nighttime blood pressure (BP) ((systolic blood pressure (SBP) \> 115mmHg))
Taking no more than 2 antihypertensive medications
African American (self-defined by the participant)
You may not be if
Secondary forms of hypertension
Presence of other diseases requiring treatment with BP lowering medication
Known cardiovascular disease (including history of angina pectoris, heart failure, presence of a cardiac pacemaker, history of myocardial infarction or revascularization procedure, or history of cerebrovascular disease, including stroke and transient ischemic attacks)
Diabetes mellitus (Type 1 or 2)
Cancer/malignancy other than nonmelanoma skin cancer
Primary renal disease
Serum creatinine \> 1.5 mg/dL in men or \> 1.4 mg/dL in women
Severe anemia
Liver enzymes \> 2.5 times upper limits of normal
Hepatitis B, Hepatitis C, or HIV positive as assessed by questionnaire
Current treatment with or regular use of calcium channel blocking agents, cyclooxygenase-2 inhibitors (COX2-I), oral contraceptives, estrogen, sildenafil, vardenafil, tadalafil, antidepressants, corticosteroids, or warfarin
Current use of melatonin or any sleep aids containing melatonin
Regular consumption (1 or more times per week) of: Vitamin methyl B12, St. Johns Wort, feverfew, black and white mustard seeds, wolf berry seed
Severe Sleep apnea
Night work
Women who are pregnant, breast feeding, attempting conception, or planning to attempt conception over the next 6 months.
