Effect of Estradiol+Drospirenone Versus Estradiol+MPA on Endothelial Function

Exclusion Criteria

• •1. Current smoking, defined as smoking within the 12 months before the screening visit;
• •2. Alcohol intake \>1 beverage per night or history of alcohol abuse;
• •3. Current or past recreational drug use;
• •4. Personal history of hypertension, cardiovascular disease (coronary artery disease, congestive heart failure, valvular heart disease, stroke, transient ischemic attack, or intermittent claudication), hyperlipidemia, diabetes (defined as a fasting glucose ≥126 mg/dL), kidney disease, liver disease, venous or arterial thromboembolic disease, adrenal insufficiency, depression, or illness requiring overnight hospitalization in the past 6 months;
• •5. Risk factors for arterial or venous thromboembolism;
• •6. Personal history of breast cancer or any other type of cancer;
• •7. Personal history of endometrial hyperplasia, endometrial cancer, or unexplained vaginal bleeding;
• •8. History of cervical cancer or abnormal pap smear
• •9. Prescription or herbal medication use, excluding thyroid hormone supplementation;
• •10. Ischemic changes on resting electrocardiogram;
• •11. Serum creatinine ≥ 1.3 mg/dL.
• •12. Serum potassium level \> 5.0 mmol/L;
• •13. Known hypersensitivity to any of the study drugs;
• •14. Other active medical problems detected by examination or laboratory testing, except for treated hypothyroidism.
• •15. Pregnancy