Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Monash University
With
Schering-Plough
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. Over 18 years of age
2. Has provided written informed consent
3. Mild to moderate hypertension (WHO Stage 1-2). Patients with mild to moderate hypertension will be either de novo presenters with this condition or withdrawn from background antihypertensive therapy for a period of 2 weeks. If sSBP is not greater than 140 mmHg after this 2 week withdrawal period (\*130 mmHg if diabetes or CKD, as per Heart Foundation of Australia Hypertension Guidelines 20082), patients can be followed, off therapy, for a further 2 weeks in order to meet this criterion. If their systolic blood pressure is above 180 mmHg they will be withdrawn from the study and will be provided with appropriate treatment.
4. Hypertensive patients with a high level of risk, i.e. having at least one of the following risk factors :
* History of CV event eg MI, stroke (\>6 months ago)
* History of revascularization procedure (\>6 months ago)
* Impaired kidney function (eGFR \<70 ml/min)
* ECG or echocardiographic evidence of LV hypertrophy
* Obesity, defined as BMI \>30 kg/m2
* Diabetes mellitus
* Peripheral arterial disease
* Macroalbuminuria
* Current smoking (defined as smoking at least 7 cigarettes per week)
5. Women must be post menopausal or using an acceptable method of contraception i.e. surgical sterilisation, hormonal contraception or double barrier method.
