Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Mississippi Medical Center
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients currently treated at the University of Mississippi Medical Center Oncology Clinic
Patient is being treated with bevacizumab either alone or in combination with other agents for cancer
Patient blood pressure is \>140 mmHg (systolic) or \> 90 mmHg (diastolic), either treated or untreated with medications for hypertension
Patients may be currently on medications for hypertension (other than Beta blocker, ACEI, or ARB); these will be continued at the same dose throughout the study
Patients should be \> 18 years of age
Patients receiving bevacizumab therapy approximately every 2 weeks
You may not be if
History of ACEI or ARB induced angioedema or idiopathic/hereditary angioedema
Patient currently treated with a Beta blocker, ACEI, or ARB or have a history of intolerance to a medication in any of these classes
Hyperkalemia, defined as a potassium value of \>5 mEq/L
Pregnancy or breastfeeding
Severe renal impairment (eGFR \<30 mL/min)
Moderate hepatic impairment as identified by physician
Currently taking CYP2D6 inducers (rifampin, carbamazepine or dexamethasone) or inhibitors (bupropion, fluoxetine, paroxetine, duloxetine, etc.)
History of clinically significant EKG abnormality which would contraindicate beta blocker use
