Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Endeavor Health
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
1. 18 years of age or older
2. Women need one of the following: negative pregnancy test or suitable birth control or post-menopausal status
3. Informed consent and ability to comply with study procedures
In order to qualify for the 6 week run-in, patients must have poorly controlled asthma as defined by the following criteria:
1. Diagnosis of asthma confirmed either by demonstrating a positive methacholine challenge test (defined as a decrease in FEV1 by at least 20%, following administration of 8mg or less of inhaled methacholine) or a positive bronchodilator response (defined as a change from base line of \>12% and at least 200ml in either FEV1 or FVC, following administration of a short-acting, inhaled bronchodilator).
2. Either:
* Asthma Control Questionnaire score \> 1.5 or
* Use of inhaled rescue ß-agonist \>/= 16 puffs per week (excluding use as a pre-medication for exercise; 1 nebulizer treatment = 2 puffs of inhaler) at any time during the past month or
* \>1 hospitalization or unscheduled MD visit in the past 6 months for asthma symptoms or
* \>1 course of oral steroid use in past 6 months or
* \> 2 weeks of systemic steroids in last 6 months.
You may not be if
1. Current smokers or those with at least a 10 pack-year smoking history
2. Presence of any concurrent diseases that, in the investigator's opinion, would interfere with participation in the study or that might put the participant at risk
