men or postmenopausal women aged between 40 and 65 years old

normal fasting blood glucose (\<100 mg/dL) and glucose tolerance test (\<140 mg/dL)

waist circumference \< 102 cm (men) or \< 88cm (women)

triglycerides \<150 mg/dL, LDL cholesterol ≤ 160 mg/dl

creatinine \<1.2 mg/dL, sinus rhythm

the presence of grade 1 or 2 of DD with an ejection fraction of left ventricle \> 55%

absence of myocardial ischemia during dobutamine stress echocardiography

Simvastatin and Diastolic Dysfunction