Treatment for Depression Among HIV-Infected Youth

Exclusion Criteria

• •Ability to understand written and spoken English; and
• •Ability and willingness to provide informed consent or assent.
• •Known or self-reported by participant to have a history of any psychotic disorder (including depression with psychotic features) and/or bipolar I or II disorder;
• •Alcohol or substance dependence based on DSM-IV criteria within the past six months as determined by treating licensed mental health clinician. Any cases that are uncertain require Protocol Team approval;
• •Pregnant or breast-feeding females;
• •Known or self-reported by participant (or parent if available) to have a first degree relative(s) with Bipolar I Disorder;
• •Depression and/or suicidal ideation requiring more intensive treatment than the study provides or at immediate risk of being a danger to themselves or others as determined by treating licensed mental health clinician;
• •Cognitive limitations, emotional instability or medical illness as determined by treating licensed mental health clinician and/or study coordinator; and
• •For Phase II only, previous participation in Phase I.
• •For participants at COMB sites only, ongoing CBT for treatment of depressive symptoms at time of study enrollment (e.g., teaching cognitive restructuring using role-play, identification of cognitive distortions, automatic thoughts, dysfunctional attitudes); and NOTE: Youth who received CBT in the past may be considered for enrollment. Any cases that are uncertain require Protocol Team approval.
• •For participants at COMB sites only, continuing antidepressant management by a site clinician who is not trained in COMB.