Study of VX-765 in Subjects With Treatment-resistant Partial Epilepsy

Exclusion Criteria

• •Subjects with a history of non-epileptic transient alterations in consciousness
• •Subjects who have a history of status epilepticus in the past 12 months
• •Subjects whose seizure frequency cannot be quantified
• •Subjects who have significant medical illness including kidney, liver, pulmonary or gastrointestinal disease; or unstable or poorly controlled conditions
• •Subjects who have clinically significant psychiatric illness
• •Subjects with a positive drug screen (excluding any allowed prescribed medications) and history of alcoholism or drug addiction within past 2 years
• •Males subjects that have a female partner of childbearing potential who do not agree to use medically approved methods of birth control
• •Male subjects that have a female partner who is pregnant, nursing, or is planning to become pregnant during the study period, or within 90 days of the last dose of study drug
• •Female subjects who are pregnant or lactating, or who are of reproductive potential who do not agree to use medically approved birth-control methods
• •Subjects with a current or prior history of illness precluding them from immunomodulatory therapy (e.g. history of recurrent infections)
• •Subjects with active hepatitis B, hepatitis C, or human immunodeficiency virus (HIV)
• •Subjects who have participated in any other clinical trials involving an investigational product or device and have received the last dose of study drug within 45 days or 5 half-lives of the Screening Visit