A Study of ABT-384 Levels and Pharmacodynamic Activity Measured in Cerebrospinal Fluid

Exclusion Criteria

• •Use of protocol-prohibited medications within 2 weeks prior to study drug administration.
• •Positive urine drug screen for non-prescribed drugs of abuse including alcohol.
• •Receipt of any drug depot by injection within 30 days prior to study drug administration.
• •Receipt of any investigational product within 6 weeks prior to study drug administration.
• •History of significant sensitivity or allergy to any drug.
• •History of drug or alcohol abuse.
• •Positive test result for HAV, HBsAg, HCV or HIV.
• •Donation or loss of 550 mL or more blood volume or receipt of any blood product within 3 months prior to study drug administration.
• •Contraindication for lumbar puncture (e.g., lumbar scoliosis, coagulopathy, infected skin at puncture site)
• •Current enrollment in another clinical study.