The Healthy Elderly Longevity Cohort

Exclusion Criteria

• •1. \< 80 years old
• •2. Participants have been previously enrolled in The Scripps Genebank Healthy Elderly Cohort
• •3. Treatment with any investigational agents or devices within thirty days preceding enrollment in the study.
• •4. Self-reported history or current diagnosis of significant chronic conditions including:
• •* Any Cancer (including polycythemia; excluding basal or squamous cell skin cancer).
• •* Coronary Artery Disease/Myocardial Infarction
• •* Stroke/TIA
• •* Deep Vein Thrombosis/Pulmonary Embolus
• •* Chronic Renal Disease/Hemodialysis
• •* Significant Auto-immune/Inflammatory conditions such as (Rheumatoid Arthritis, Lupus, Crohn's, etc.
• •* Alzheimer's/Parkinson's
• •* Diabetes (Hemoglobin A1C \> 6.5 % or fasting glucose \>126 mg/dL or treated with oral diabetic medication or insulin if known)
• •* Aortic or Cerebral Aneurysm
• •5. Currently taking any of the following medications on a regular basis:
• •* Oral chemotherapeutic agents (ex.: tamoxifen, doxorubicin, mitoxantrone, bleomycin)
• •* Anti-platelet agents, not including aspirin (ex.: clopidogrel/plavix, dipyridamole/aggrenox/persantine, ticlopidine/ticlid)
• •* Cholinesterase inhibitor for Alzheimer's disease (i.e. donepezil/Aricept)
• •* Insulin
• •6. Subject has a significant medical condition which, in the Investigator's opinion, may interfere with the patient's optimal participation in the study or would potentially confound interpretation of the individual's phenotype.