Quality of Life and Self-esteem After Botox® Injections in Depressed and Non-depressed Patients

Inclusion Criteria

• •1. Female subjects,aged between 25 to 60 years;
• •2. Subjects diagnosed as having major depression according to the criteria of DSM-IV, MINI International Neuropsychiatric Interview (MINI Brazilian version 5.0.0);
• •3. Subjects who are being administered a therapeutic dose of an approved, prescribed antidepressant medication (pattern doses of the literature), and have been using mentioned medication at a stable therapeutic dose for at least three months prior to the randomization visit;
• •4. Subjects with mild (1), moderate (2) or severe (3) glabellar frown lines while at rest according the Severity Wrinkles Scales;
• •5. Female subjects of childbearing age that present a negative urine pregnancy test and are using an effective contraceptive method;
• •6. Subjects who had never received botulinum toxin A previously;
• •7. Subjects agreeing to take part of the study, after being fully informed of the purpose and the nature of the investigation and after having signed the informed consent form;
• •8. Subjects who will be available throughout the duration of the study;
• •9. Subjects with sufficient schooling and awareness to enable them to cooperate to the degree required by this protocol;
• •10. Subjects with Critical appreciation preserved, attested by their assistant psychiatrist (for group1);
• •11. Subjects who reside with other family members who assume co-responsibility in the study.