Chromium's Effect on Insulin Resistance in Obesity

Exclusion Criteria

• •1. positive pregnancy test (all women must have a negative pregnancy test before beginning protocol);
• •2. diagnosis of cancer;
• •3. acute illness of any sort, however, patients may be enrolled once they are stable;
• •4. hemoglobin less than 11.0 g/dl or hemodynamically unstable;
• •5. creatinine greater than or equal to 1.5 mg/dl;
• •6. liver dysfunction as evidenced by elevations in transaminases 2-fold higher than upper limit of normal;
• •7. use of certain medications within the past month (e.g., glucocorticoids).
• •8. untreated hypertension (systolic BP \> 150 mmHG, diastolic BP\>IOO mmHG);
• •9. patients with diabetes mellitus;
• •10. hypogonadism;
• •11. abnormal thyroid function (serum T4 \< 4 or \> 12; TSH \< 0.35 or \> 5.5) (12) any chronic liver or kidney disease; OR
• •12. polycystic ovarian syndrome.