Study Evaluating the Tolerance and Biologic Activity of Oral Ciclopirox Olamine in Patients With Relapsed or Refractory Hematologic Malignancy

Exclusion Criteria

• •1. Uncontrolled systemic infection.
• •2. Uncontrolled intercurrent illness
• •3. Pregnant or breast feeding
• •4. Active CNS (central nervous system) disease
• •5. Neurologic symptoms related to intracurrent illnesses or unexplained causes
• •6. Psychiatric illness that would limit compliance with study
• •7. Receiving other systemic chemotherapy, other than hydroxyurea to control circulating blast counts, within 10 days of study entry. Hydroxyurea is permitted, however the dose must be stable and unchanged in the 7 days prior to initiation with ciclopirox olamine
• •8. Concurrent therapy with topical ciclopirox olamine.
• •9. Use of other investigational anti-cancer therapy within two weeks of study entry.
• •10. Use of oral or intravenous metal supplements including iron, copper, zinc and nickel.
• •11. Resting ejection fraction \< 50%