Xenin-25: Novel Regulator of Insulin Secretion and Beta-cell Function

Exclusion Criteria

• •\<18years of age or \>65 years of age
• •Lacks cognitive ability to sign the consent \&/or follow the study directions for themselves
• •Women unwilling to comply with using an acceptable method of contraception during the course of the study, or who are currently breast-feeding.
• •Any subject whose screening HbA1c is \>9.0%
• •Type 2 diabetes requiring the use of supplemental insulin @ home
• •Volunteers with a history of Acute Pancreatitis
• •Volunteer with a history of Chronic Pancreatitis and/or risk factors for chronic pancreatitis including hypertriglyceridemia (triglycerides \>400mg/ml) hypercalcemia (blood calcium level \>11.md/dl) and/or the presence of gallstones.
• •Volunteers with a history of gastrointestinal disorders, particularly related to gastric motility/emptying such as gastric bypass, documented gastro-paresis in diabetic volunteers.
• •Volunteers with a history of cancer. Exception: skin cancer.
• •Diabetics that have the potential to have a low blood sugar without them being aware that their blood sugar is low (hypoglycemia unawareness).
• •Known heart, kidney. liver or pancreatic disease requiring medications.
• •Subjects unwilling to allow the use of their own blood or the human albumin in the preparation of the peptides.
• •Unwillingness to allow blood glucose level adjustment (if needed) with IV insulin.