Combined Non-invasive Coronary Angiography and Myocardial Perfusion Imaging Using 320 Detector Computed Tomography

Exclusion Criteria

• •Known allergy to iodinated contrast media.
• •History of contrast-induced nephropathy.
• •History of multiple myeloma or previous organ transplantation.
• •Elevated serum creatinine (\> 1.5 mg/dl) OR calculated creatinine clearance of \< 60 ml/min (using the Cockcroft-Gault formula.
• •Atrial fibrillation or uncontrolled tachyarrhythmia, or advanced atrioventricular block (second or third degree heart block).
• •Evidence of severe symptomatic heart failure (NYHA Class III or IV); Known or suspected moderate or severe aortic stenosis.
• •Previous coronary artery bypass or other cardiac surgery.
• •Coronary artery intervention within the last 6 months.
• •Known or suspected intolerance or contraindication to beta-blockers including:
• •* Known allergy to beta-blockers
• •* History of moderate to severe bronchospastic lung disease (including moderate to severe asthma).
• •Severe pulmonary disease (chronic obstructive pulmonary disease).
• •Presence of any other history or condition that the investigator feels would be problematic.
• •SPECT preformed in non-validated center within 60 days prior to screening.
• •SPECT performed within the previous 6 months of screening but \> 60 days.
• •SPECT studies performed within 60 days of screening that include rest and stress studies performed using 2 day protocols.
• •BMI greater than 40