Study of the Intradermal Injection of rHuPH20 or Placebo in Participants With Nickel Allergic Contact Dermatitis

Inclusion Criteria

• •Females 18-60 years of age. Females of child-bearing potential must use a standard and effective means of birth control for the duration of the study.
• •Known contact dermatitis to nickel with a confirmed positive patch-test result to nickel sulfate.
• •Intact normal skin without potentially obscuring tattoos, acne, dermatitis, pigmentation or lesions on the posterior aspect of the torso (back) in the area intended for allergen testing and dose administration.
• •Vital signs (blood pressure \[BP\], heart rate \[HR\], temperature, respiratory rate) within normal range or, if out of range, assessed by the Investigator as not clinically significant and it is mutually agreed by both Investigator and sponsor medical monitor that the participant need not be excluded from the study for this reason.
• •A negative serum or urine pregnancy test (if female of child-bearing potential) within 14 days of initial study drug administration.
• •Participant should be in good general health based on medical history and physical examination, without medical conditions that might prevent the completion of study drug injections and assessments required in this protocol.
• •Decision-making capacity and willingness and ability to comply with the requirements for full completion of the study.
• •Signed, written Institutional Review Board (IRB)/Ethics Committee (EC)-approved informed consent.