Severe asthmatics as defined by an FEV1 ≤ 60% or PEF variability \> 30% or with continual daytime or nocturnal symptoms.

Nasal Polyposis grade 2/3, deviated nasal septum ≥ 50%

The use of oral corticosteroids within the last 3 months

Recent respiratory tract infection (2 months)

Significant concomitant respiratory disease

Any other significant medical condition or investigation which may jeopardise the safety of the participant or the conduct of the protocol

Any significant abnormal laboratory result as deemed by the investigators

Pregnancy, planned pregnancy or lactation

Known or suspected contra-indication to any of the IMP's

Concomitant use of medicines (prescribed, over the counter or herbal) that may interfere with the trial

Steroid Sparing Effect of Nasal Corticosteroid In Asthma And Rhinitis